Ligands for Target Protein for PROTAC
Target Protein-binding Moiety
The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.
Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).
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Ligands for Target Protein for PROTAC Inhibitors
(3)
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Ligands for Target Protein for PROTAC Chemicals
(6)
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Ligands for Target Protein for PROTAC Degrader
(1)
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Ligands for Target Protein for PROTAC Controls
(9)
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Ligands for Target Protein for PROTAC Ligands
(12)
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Ligands for Target Protein for PROTAC Related Products (686)
Related Products (686)
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Related Compound Screening Libraries (1)
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iFSP1 (Standard)
0 ImagesCat. No.: HY-136057RCAS No.: 150651-39-1iFSP1 (Standard) is the analytical standard of iFSP1 (HY-136057). This product is intended for research and analytical applications. iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC50 of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout cells which overexpressed FSP1. iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R)-RSL3 (HY-100218A).
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MS417 (Standard)
0 ImagesCat. No.: HY-111139RCAS No.: 916489-36-6Synonyms: GTPL7512 (Standard)MS417 (Standard) is the analytical standard of MS417 (HY-111139). This product is intended for research and analytical applications. MS417 is a selective BET-specific BRD4 inhibitor, binds to BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively, with weak selectivity at CBP BRD (IC50, 32.7 μM).
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SOS1 Ligand intermediate-6
0 ImagesCat. No.: HY-163583CAS No.: 3036156-01-8SOS1 Ligand intermediate-6 is an intermediate for the synthesis of SOS1 ligand and can be used to synthesize PROTACs.
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PROTAC BET-binding moiety 1 (Standard)
0 ImagesCat. No.: HY-107451RCAS No.: 2093387-77-8
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SMARCA2 ligand-7
0 ImagesCat. No.: HY-159544CAS No.: 2568281-41-2
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CDK7 ligand 1
0 ImagesCat. No.: HY-161829CDK7 ligand 1 is an active control ligand for CDK7 ligand 2 (HY-161830). CDK7 ligand 2 is a CDK7 ligand. CDK7 ligand 2 can be used in the synthesis of PROTACs.
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PROTAC Her3-binding moiety 1 (Standard)
0 ImagesCat. No.: HY-107444RCAS No.: 1603845-36-8
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7α,25-Dihydroxycholesterol intermediate-1
0 ImagesCat. No.: HY-400897CAS No.: 1326612-12-77α,25-Dihydroxycholesterol intermediate-1 is an intermediate in the synthesis of 7α,25-Dihydroxycholesterol (HY-113962). 7α,25-Dihydroxycholesterol (7α,25-OHC) can be used as a ligand to target the orphan GPCR receptor EBI2 (GPR183). body, used to synthesize the corresponding PROTEACs.
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AR ligand-51
0 ImagesCat. No.: HY-139444CAS No.: 2616553-29-6AR ligand-51 is an androgen receptor ligand, which can be used for the synthesis of PROTACs, such as ARD-2585 (HY-139436).
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WDR5 ligand 2
0 ImagesCat. No.: HY-168488CAS No.: 2737222-78-3WDR5 ligand 2 is the ligand for WDR5 and can be used for synthesis of PROTAC WDR5 degrader 1 (HY-168487).
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VUBI1 (Standard)
0 ImagesCat. No.: HY-111671RCAS No.: 2245237-53-8Synonyms: SOS1 activator 1 (Standard)VUBI1 (Standard) is the analytical standard of VUBI1 (HY-111671). This product is intended for research and analytical applications. VUBI1 (SOS1 activator 1) is a benzimidazole derivative and SOS1 activator with a Kd of 44 nM. VUBI1 can significantly activate RAS-GTP and regulate the phosphorylation of ERK. VUBI1 also can serve as a target ligand for synthesizing PROTACs, such as PROTAC SOS1 degrader-1 (HY-145737), to induce SOS1 degradation. VUBI1 can be used in the study of cancer.
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(R)-PROTAC CDK9 ligand-1
0 ImagesCat. No.: HY-115729ACAS No.: 2411021-95-7
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BRD9 ligand-13
0 ImagesCat. No.: HY-175915CAS No.: 2704619-67-8BRD9 ligand-13 (Compound 5) is a BRD9 ligand that can be used for the synthesis of PROTACs, such as PROTAC BRD9 Degrader-8 (HY-162651).
